5- HTP and L-DOPA ADMINISTRATION INFLUENCE REPRODUCTIVE STATE IN DOMESTIC PIGEON, COLOUMBA LIVIA DOMESTICA

Adreno gonadal hypothalamo hypophyseal axis was tested in female monogamous bird domestic pigeon Columba livia domestica,. Two neurotransmitter precursor drugs (5-HTP and L-DOPA) were used at different time intervals. Female birds were divided in to three groups, having eight individuals in each group. Group 1 was control group received only vehicle. Group II was 0 hr group administered with 5-HTP and L-DOPA at 0 hr interval. Group III was 8 hr group and received these neurotransmitter precursor drugs i.e. 5-HTP and L-DOPA at 8 hr interval. Quantity of doses was 0.5mg/ kg body weight in 0.1 ml normal saline. Experimentations were terminated after 13 days and results were obtained 45 days after experimentation. 0 hr group showed significantly stimulatory (P<0.05) responses in body weight and plasma estrogen level, while 8 hr group showed significantly inhibitory (P<0.05) effect in comparison to control. Cholesterol and ascorbic acid contents in ovarian follicles and adrenal gland were found significantly low (P<0.05) in 0 hr group while significantly high (P<0.05) in 8 hr group in comparison to control. Regressive stages of adrenal gland by administration of neurotransmitter precursor drugs at 8 hr interval and progressive stages at 0 hr interval indicate possibility of changes in temporal synergism between adrenogonadal axis of hypothalamus. Also, it may exert reproductive stress with and without season of reproduction in this seasonal bird.